One of the largest ever genetic replication studies of bipolar affective disorder has resulted in a significant discovery. It has found compelling evidence that the chromosome known as the 3p21.1 locus contains a common genetic risk for bipolar disorder, the PBRM1 gene. This means, from using a separate dataset of over 34,000 subjects, that there appears not to be an association of this same variant with schizophrenia.

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