149 people with bipolar disorder took 2000 mg per day of NAC along with their regular medications for eight weeks. On average, participants experienced a 46 per cent reduction in their depressive symptoms based on the Bipolar Depression Rating Scale. Similarly, on a measure of quality of life and of general functioning, significant improvements were reported.

N-acetylcysteine (NAC) is an antioxidant most commonly used to clear mucus from airways and to treat paracetamol overdose.

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