Mania Symptom Profile Changes with Age

Catching up on my reading, I came across an article on News-Medical.net posing the argument that the Bipolar patient’s mania symptom profile changes with age.  The study found that compared with adults, adolescents (aged 10-17 years) with bipolar I disorder had significantly higher YMRS item scores – relative to the total score – for aggression and irritability.  Conversely, YMRS grandiosity and sexual interest item scores were higher in adults than adolescents.

Upon reflection it became clear that their findings mirror my experience with Bipolar Disorder.  While in my late teens and early 20′s, becoming agitated was something I dreaded.  Not only would I awake every morning wondering what kind of day my mood would allow me to have, I was always on edge waiting for the inevitable spark to set me off and bring with it bouts of screaming, china-smashing and risky-behavior I came to dread.  When I was young, my mania was a much more physical thing.  I’m amazed my family never tried to have me hospitalized.  I think my worst manic experience came when I was 21 or so.  I clearly remember driving like a lunatic in a 25 mph zone and daring myself to crash into a tree.  I almost did it, too.  I’ll never know what stopped me but that is the point where I decided I needed help and saw a doctor.

As I’ve aged, as the study points out, the manias haven’t mellowed, their dynamic has simply changed.  Grandiosity is really the main feature now – whether it is taking on a grand project that allows for no sleep until completed or believing in some grand life-circumstance that simply isn’t there. I would say the risky behavior has turned in on itself and become a form of grandiosity that a handful of times has bordered on psychosis.  The bottom line is if one were to diagram my journey through mania over the last two-and-one-half decades, today’s points of interest are not what they were twenty-five years ago.

I’m encouraged that the conclusion of the study states,

“Age-grouped differences in the assessment of bipolar manic disorder need to be taken into account to better understand the psychopathology of mania and to build consistent diagnostic criteria for community care.”

Keeping in mind another recent study that puts the average diagnosis time of Bipolar at 13.5 years from first onset of symptoms, I can’t help feel that one benefit of putting in place more granular, age-aware criteria for mania may make it possible for some individuals to be diagnosed sooner.

Another thing this study makes abundantly clear is that Bipolar is a very fluid disease.  Cycle time, wellness period length, episode features and the meds required for an effective cocktail are always changing.  Those of us living with Bipolar must be forever vigilant and be agile enough to react appropriately to whatever our disease throws at us in order to maintain optimum mental health.  Which, quite frankly, is pretty exhausting, but that is fodder for another post.

Abilify Withdrawal – Round 1

Ding.

After three of my Drs finally consulted together and deemed Abilify the evil, weight-gain drug I always knew it was, with my psychiatrist’s blessing I started to decrease my dose.  I thought about not writing about my withdrawal experience, but hopefully this post may provide to some a bit of the first-hand info I was looking for a few months back.

I complain about Abilify a lot, but first let me say the med isn’t entirely spawn from the Devil.  It definitely has an important place in my history.  It was wonderful for stopping my mild psychosis cold turkey and keeping me on a stable plane when I needed it the most.

The trouble with Abilify – as with pretty much all the drugs in the anti-psychotic class – is it makes you gain weight.  Sometimes a lot of weight.  And when you’re already battling self-esteem issues and have some heavyweight health issues in your family tree, that’s not at all desirable. After 32 pounds I said, “Enough.”  It also makes you feel medicated.  Very medicated.  My memory is practically nonexistent, so that was another driver for wanting off of this med.

Several people warned me that going off of Abilify wasn’t going to be easy.  They are right.  Although it took a relatively small dose to keep me stable (7.5 mg), that translates to even small incremental dosing changes having big impacts.  My personal experience is that a 2.5 mg drop in dose resulted in confusion, motion sickness, vision disturbances and generally feeling pretty horrible.  I was on the lower dose for only four days and had to retreat back to 7.5 mg and regroup.  Be forewarned, if you have something important (like visitors coming) or stressful (be it good or bad stress) then it is not the time to try to titer down.

One positive effect was the water weight did begin to drop.  At the rate of one pound per day, even though I was keeping up my liquid consumption.  Just goes to show that my muffin face is not the product of too many baked goods ( :) ).

After consulting with my psychiatrist, we have agreed on the every-other-day plan of attack.  That means 7.5 mg one day, 5 mg the next, lather-rinse-repeat for two weeks.  Then we’ll reassess.

The moral of the story is if you’re trying to wean off of Abilify, be patient and vigilant for any unusual side effects.  And, be willing to adjust your dose up again if things aren’t going your way.

Round 2 began yesterday evening.  Stay tuned.  Hopefully the every-other-day angle will be more successful.

Should Depressed People Avoid Having Children?

Few women will ever be in this position, however at one point in my life I was asked to donate my eggs to a person who was having tremendous fertility difficulties. I was in my early 30′s. Although I love the person who asked and was physically healthy as a horse, I immediately and adamantly declined the request for the sole reason I decided never to potentially pass along the suffering that comes with having a mental illness. Since my own Bipolar struggle increased ten-fold after my pregnancy and my son suffers from depression, to this day I am very much a peace with my decision not to donate my eggs.

Should depressed people avoid having children?

It’s a compelling and very individual question. There isn’t any doubt that for some depression is the catalyst for greatness. But, at a very high price. Whatever your opinion, I applaud Sarah Silverman for her candor. She certainly knows herself better than most of the people I’m acquainted with, mental illness sufferers or not.

WordPress Trashes Another Post

Sorry, Gang.

I had a nice post all ready to go for you.  Not another news article, either.  A real, honest-to-goodness post.

Then, I made the mistake of hitting Save Draft.

Silly me.

The entire post was irrevocably lost.  This is not the first time WordPress has done this to me, either.

So, rather than sit for another hour and try to recreate what is lost, I figured I would sponsor a crank session and have all of you pour out your stories about your most frustrating WordPress experiences.

Ready, set – GO!

[BTW, I'm just hitting Publish this time.]

‘Mad’ scientists find out why geniuses go ‘mad’

In the report, a group of panelists at the annual World Science Festival in New York on Thursday said that a previous study in 2010 indicated that smarter people were more likely to develop bipolar disorder.

“They found that people who excelled when they were 16 years old were four times as likely to go on to develop bipolar disorder,” said psychologist Kay Redfield Jamison from Johns Hopkins University of Medicine, who suffers from the disease herself. The study was conducted on 700,000 Swedish teenagers.

Read the entire article here